Celecoxib, rofecoxib, and acute temporary visual impairment

COX-2 inhibitors celecoxib and rofecoxib prevent oxidative DNA fragmentation.

BACKGROUND Cyclooxygenase (COX) is the key regulatory enzyme in prostaglandin (PG) synthesis and is up-regulated in many premalignant and malignant lesions. The aim of this study was to investigate the in vitro DNA protective or damaging effects of COX-2 inhibitors using the single-cell gel electrophoresis (Comet) assay. MATERIALS AND METHODS Cells from miniorgan cultures of pharyngeal mucosa...

The effect of visual impairment on emotional development and emotional competence in learners who are visual impairment

Abstract Background and Aim: Emotion is a strong affective perception or feeling that arises from personal circumstances, one's mood, or communication with others. Emotions are multidimensional and have holistic structures that consist of different dimensions such as behavioral expression, physiological layers, phenomenological experience, cognitive processes and social context. The aim of ...

Rofecoxib, 25 mg/d, was more effective than rofecoxib, 12.5 mg/d, celecoxib, or acetaminophen in osteoarthritis of the knee.

Patients 382 patients > 40 years of age (mean age 63 y, 68% women) who had symptomatic OA of the knee for > 6 months (American College of Rheumatology criteria and functional class rating of I, II, or III), used non-steroidal anti-inflammatory drugs (NSAIDs) or high dose acetaminophen for > 30 days before study entry, and met relevant entry criteria based on the Western Ontario and McMaster Uni...

Review: risk for cardiovascular events is increased with rofecoxib, diclofenac, and indomethacin but not celecoxib.

Economic Assessment: Celecoxib and Rofecoxib for Patients with Osteoarthritis or Rheumatoid Arthritis